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Medetomidine Overdose: Why More Naloxone Is Not the Answer—But Timely Respiratory Support Is

JEMS

When combined with fentanyl, it can cause profound sedation, respiratory depression, and hemodynamic compromise—and naloxone doesn’t reverse it. For EMTs and paramedics, this growing trend requires a shift in how we recognize and respond to overdose syndromes. What Is Medetomidine? Where Is It Showing Up?