ACEP Now
AUGUST 4, 2025
Neffy First off the rack is Neffy (epinephrine), whose name is more reminiscent of a child’s plush toy than a pharmaceutical. Regardless, Neffy is approved as an intranasal delivery system for epinephrine primarily for the treatment of anaphylaxis. Development of neffy, an epinephrine nasal spray, for severe allergic reactions.
JEMS
JULY 16, 2025
Their Guardian system can deliver critical emergency supplies—Narcan, epinephrine, blood products, AEDs—direct to incident scenes faster than ground crews can arrive. This capability can mean the difference between life and death in overdose, allergic reaction, or trauma incidents.
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ACEP Now
MAY 9, 2025
mcg/kg IV for 30 minutes Platelet function analyzer-epinephrine decreased from 192 to 124 seconds (p=0.01), which is consistent with a resolution of an aspirin effect. mcg/kg IV infused over 30 minutes Onset: within 30 minutes Peak effect: 1.5-2 vs 25%; p=0.31) No difference in thrombotic events (3.6% vs 5.1%; RR Feldman E, et al; 2019.
ACEP Now
JULY 2, 2025
Local reaction treatments are generally treated supportively with local corticosteroids and antihistamines. If more generalized allergic reactions occur, treat with standard oral antihistamines and steroids. Anaphylaxis treatment is again standard, with epinephrine and intravenous antihistamines as indicated. Nat Commun.
Core EM
OCTOBER 16, 2024
Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3%
REBEL EM
JUNE 14, 2023
Anaphylactic Shock is an acute, life-threatening hypersensitivity disorder, with a generalized, rapidly evolving, multi-systemic allergic reaction (IgE-mediated disorder). If not treated rapidly can become fatal.
REBEL EM
DECEMBER 5, 2023
How Long Should We Monitor After Giving IM Epinephrine for Anaphylaxis? Bottom Line Up Top: After prompt recognition and appropriate treatment with IM epinephrine, the risk of biphasic reactions are exceedingly low. At the time of discharge, appropriate patient education and prescriptions for IM epinephrine are essential.
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