TNK vs tPA — The ORIGINAL Trial
REBEL EM
APRIL 29, 2025
Clinical Bottom Line TNK was non-inferior to tPA for excellent outcomes (mRS 01 at 90 days) High proportion of mild strokes may introduce spectrum bias, making non-inferiority easier to demonstrate Slightly more TNK patients treated within 3 hours could affect results No difference in mortality, bleeding, or serious adverse events Findings support TNK as an alternative to tPA Introduction The American Heart Association and the European Stroke Organization have updated their guidelines to recomm
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