ACEP Now

MAY 9, 2025

DDAVP causes release of endogenous coagulation factors such as factor VIII, von Willebrand factor (vWF), and tissue plasminogen activator (tPA) which increases plasma factor levels, enhances platelet adhesion, and reduces bleeding time. mL One patient had hypotension (7%) and another had a new fever within 6 hours of infusion start Dr.

Allergic Reaction

REBEL EM

SEPTEMBER 13, 2023

Bradykinin Mediated Plasma globulins called kininogens release bradykinin and cause vascular permeability. Image: ( Morgan 2010 ) Features Absence of urticaria and pruritus Insidious onset (24-36 hours) ACE Inhibitors Inhibition of ACE hinders the degradation of bradykinin and can lead to idiosyncratic angioedema.

Frozen Plasma

Core EM

OCTOBER 16, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction

EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] If epinephrine is used, small initial doses ( <1 ug/kg) are preferred.

E-9-1-1

The Overrun Podcast

MAY 23, 2019

Qasim is on Twitter at: @emeddoc Dr. Callelo: @DrDianeC, @njpoisoncenter, also at @ToxAndHound The COMBAT trial for prehospital plasma: [link] The PAMPHER trial: [link] BOKUTOH criteria study: [link] PARAMEDIC2 study of Epinephrine in OHCA: [link] Pediatric airway management in cardiac arrest: [link] Heads up CPR in OHCA: [link] And, why it may NOT (..)

EMS

Core EM

OCTOBER 2, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction

EMDocs

DECEMBER 18, 2023

The first was the suggestion to use balanced crystalloid fluids, such as lactated ringers or plasma-lyte, instead of normal saline. 34 If a MAP of 65 mmHg is still not achieved, epinephrine should be added as a third agent (Figure 1). 15 Two changes were elucidated in the 2021 SSC guidelines for fluid resuscitation. units/minute.

E-9-1-1