Frozen Plasma and Plasma - Paramedicine Now

A guide to major haemorrhage management in paediatrics

Don't Forget the Bubbles

OCTOBER 28, 2024

Major haemorrhage protocols typically include a mixture of packed red blood cells (pRBCs), platelets, and fresh frozen plasma (FFP). Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. 2024;19(5):e0303109.

Frozen Plasma

Frozen Plasma FFP Plasma ALS

ED care of refugee populations from sub-Saharan Africa

EMDocs

JANUARY 6, 2025

GI symptoms, right upper quadrant abdominal pain, jaundice. ^ = AMB, a region of sub-Saharan Africa consisting of > 20 countries which have an unusually high incidence of bacterial meningitis and frequency of outbreaks; nearly half of global bacterial meningitis cases occur in the AMB. Severe malaria management. WHO Guidelines for Malaria.;

ED

ED E-9-1-1 ALS Frozen Plasma

ToxCard: Iron

EMDocs

DECEMBER 6, 2024

Antidote : Deferoxamine is a chelating agent derived from Streptomyces pilosus ; binds free iron from plasma and iron inside of cells. Coagulopathy: Parenteral vitamin K and/or fresh frozen plasma (FFP) as clinically indicated. 9 Typical dose: Polyethylene glycol (Go-Lytely ) 25 mL/kg/hr in small children and 1.5-2

E-9-1-1

E-9-1-1 Frozen Plasma Plasma Overdose

EM@3AM: Systematic Approach to Massive Hemorrhage and Nuances in Special Patient Populations

EMDocs

MAY 17, 2025

Balanced transfusion of packed red blood cells (PRBCs), platelets and fresh frozen plasma (FFP) in a 1:1:1 ratio is the current best practice to avoid inducing coagulopathy by large volume blood product administration. 17 TEG and ROTEM are non-invasive tests that quantitatively measure the ability of whole blood to form a clot.

E-9-1-1

E-9-1-1 EMS FFP Frozen Plasma

Severe Malaria: ED Presentation, Evaluation, and Management

EMDocs

MAY 27, 2025

11 Transfuse patients who are anemic or coagulopathic, ideally with fresh whole blood; if this is not available, use packed red blood cells (PRBCs) for anemia, and replete coagulopathy with platelets, fresh frozen plasma (FFP), or cryoprecipitate as indicated. Severe Malaria 11 Defined as the presence of P.

ED

ED Plasma Frozen Plasma ALS

Podcast 185.0: Anticoagulation Reversal

Core EM

JANUARY 25, 2024

Comparison between Prothrombin Complex Concentrate (PCC) and Fresh Frozen Plasma (FFP) for the Urgent Reversal of Warfarin in Patients with Mechanical Heart Valves in a Tertiary Care Cardiac Center. Iran J Pharm Res. 2015;14(3):877-885. Fariborz Farsad B, Golpira R, Najafi H, et al.

Frozen Plasma

Frozen Plasma FFP Plasma Critical Care

SGEM#251: Nothing Compares to You…Because there was No Comparison Group

The Skeptics' Guide to EM

APRIL 6, 2019

In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozen plasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). This changed in 2015 when the Food and Drug Administration (FDA) approved idarucizumab for the reversal of dabigatran.

Frozen Plasma

Frozen Plasma Plasma ALS EMS

REBEL Core Cast 108.0 – Angioedema

REBEL EM

SEPTEMBER 13, 2023

Bradykinin Mediated Plasma globulins called kininogens release bradykinin and cause vascular permeability. Image: ( Morgan 2010 ) Features Absence of urticaria and pruritus Insidious onset (24-36 hours) ACE Inhibitors Inhibition of ACE hinders the degradation of bradykinin and can lead to idiosyncratic angioedema.

Frozen Plasma

Frozen Plasma Allergic Reaction FFP Plasma

Anticoagulation Reversal

Core EM

JANUARY 24, 2024

Background Around 6 million people in the U.S. 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways.

FFP

FFP Frozen Plasma Plasma ALS

Guideline Update: Acute Lower GI Bleeding

EMDocs

NOVEMBER 20, 2023

For patients on VKAs to prevent stroke in nonvalvular atrial fibrillation who require reversal, 4-factor prothrombin complex concentrate (PCC) is preferred to fresh frozen plasma (FFP) because of the rapidity of INR reduction (Conditional recommendation, very low-quality evidence).

Frozen Plasma

Frozen Plasma FFP Plasma OR

Thrombotic Thrombocytopenic Purpura (TTP)

Core EM

JANUARY 25, 2024

Joly, 2017; Sawler, 2020) Fresh frozen plasma (FFP) (contains ADMTS-13) may be used to supplement ADAMTS-13 if there is a delay in initiating TPE in the emergency department (i.e. Decreases production of anti-ADAMTS13 antibodies by removing the B cells that mature into autoantibody-secreting plasma cells. Thrombosis Research.

Plasma

Plasma Frozen Plasma Emergency Department FFP

SGEM386: Blood on Blood – Massive Transfusion Protocols in Older Trauma Patients

The Skeptics' Guide to EM

DECEMBER 17, 2022

The transfusion tech calls to remind you that your protocol is currently under review, and asks if would you like the 1:1 or the 1:3 version of fresh-frozen plasma (FFP) to packed red blood cells (pRBC)? Noting with some relief that at least he isn’t anticoagulated, you activate the hospital massive transfusion protocol.

Frozen Plasma

Frozen Plasma FFP Plasma Emergency Medical Services

Data Café Insights: Whole Blood and PRBC Usage

ESO

MARCH 15, 2024

They received fewer PRBCs, fresh frozen plasma (FFP), and platelets across their LOS, while total units and volumes were similar. Balance resuscitation strategy, often in a 1:1:1 ratio of PRBCs with fresh frozen plasma and platelets.

Frozen Plasma

Frozen Plasma Plasma FFP OR

REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?

REBEL EM

JUNE 26, 2023

Reversal of Trauma-Induced Coagulopathy Using First-Line Coagulation Factor Concentrates or Fresh Frozen Plasma (RETIC): A Single-Centre Parallel-Group, Open-Label Randomised Trial. PMID: 36942533 Innerhofer P et al. Lancet Haematol 2017. PMID: 28457980 Jehan F et al.

FFP

FFP Frozen Plasma ALS Plasma

Snake Bites and Children

Pediatric EM Morsels

MARCH 17, 2023

(Judge 2019) Best when given within 4 hours of the bite, but still effective within 24 hours Always give an entire vial of antivenom, never a partial vial. It’s expensive, so if you’re giving some of a vial, give it all.

Frozen Plasma

Frozen Plasma Plasma First Aid ICU

Recognition and Treatment of Thrombotic Thrombocytopenic Purpura

ACEP Now

APRIL 5, 2024

Therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) is the first-line treatment, by simultaneously supplying fresh ADAMTS13 and removing anti-ADAMTS13 autoantibodies. Therapeutical plasma exchange for thrombotic thrombocytopenic purpura in the emergency department: A single center experience. 2021;10(3):536.

Frozen Plasma

Frozen Plasma Plasma FFP Emergency Department

Best Practices for Upper Gastrointestinal Hemorrhage

ACEP Now

NOVEMBER 16, 2023

Fresh frozen plasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.”

Frozen Plasma

Frozen Plasma FFP ALS Plasma

Unstable Pelvic Trauma Patient: ED Presentations, Evaluation, and Management

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. 13 Massive transfusion protocols (MTP) are hallmarks of trauma resuscitation, and they are critical to the unstable pelvic fracture patient.

ED

ED Operating Room ALS Frozen Plasma

FARES II: PCC vs FFP in Cardiac Surgery

The Bottom Line

MAY 23, 2025

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery The FARES-II Multicenter Randomized Clinical Trial Karkouthi. JAMA 2025; doi:10.1001/jama.2025.3501

FFP

FFP Frozen Plasma Plasma OR

ABA Annual Meeting to Spotlight Innovation and Engagement in Burn Care

American Burn Association

MARCH 26, 2025

Does Adding Fresh Frozen Plasma to Burn Resuscitation Improve Outcomes in Thermal Injury?; Testosterone Therapy for Major Burn Injury; 2. What You Wear Underneath Your Gear Matters; 3. Cutaneous Functional Unit (CFU) Burn Features Linked to Motion Loss at Hospital Discharge; 4.

Frozen Plasma

Frozen Plasma Plasma Firefighter ED

Paramedicine Now

A guide to major haemorrhage management in paediatrics

ED care of refugee populations from sub-Saharan Africa

Trending Sources

ToxCard: Iron

EM@3AM: Systematic Approach to Massive Hemorrhage and Nuances in Special Patient Populations

Severe Malaria: ED Presentation, Evaluation, and Management

Podcast 185.0: Anticoagulation Reversal

SGEM#251: Nothing Compares to You…Because there was No Comparison Group

REBEL Core Cast 108.0 – Angioedema

Anticoagulation Reversal

Guideline Update: Acute Lower GI Bleeding

Thrombotic Thrombocytopenic Purpura (TTP)

SGEM386: Blood on Blood – Massive Transfusion Protocols in Older Trauma Patients

Data Café Insights: Whole Blood and PRBC Usage

REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?

Snake Bites and Children

Recognition and Treatment of Thrombotic Thrombocytopenic Purpura

Best Practices for Upper Gastrointestinal Hemorrhage

Unstable Pelvic Trauma Patient: ED Presentations, Evaluation, and Management

FARES II: PCC vs FFP in Cardiac Surgery

ABA Annual Meeting to Spotlight Innovation and Engagement in Burn Care

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