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REBEL Core Cast 108.0 – Angioedema

REBEL EM

Features Urticaria and pruritis Rapid onset (1-2 hours) IgE Dependent (Type I Hypersensitivity) Reactions An allergen cross-links two or more IgE molecules on mast cells or basophils and initiates a signal cascade leading to degranulation. Without the C1 inhibitor, the plasma-kallikrein-kinin system produces more bradykinin.

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ToxCard: Local Anesthetic Systemic Toxicity

EMDocs

1-5] Since then, many more medications have been developed and deployed. Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2]

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EM@3AM: Endometritis

EMDocs

1997 Mar;11(1):203-22. Plasma cell endometritis is associated with Chlamydia trachomatis infection. 1985 Dec 1;153(7):737-9. Kankuri E, Kurki T, Carlson P, Hiilesmaa V. 2024, [link] Mackeen AD, Packard RE, Ota E, Speer L. PMID: 10805361; PMCID: PMC1784665. Casey BM, Cox SM. Chorioamnionitis and endometritis.

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Utility of D-dimer Testing in Special Populations

EMDocs

1 A D-dimer level can, therefore, be used as a non-specific and indirect biomarker for the presence of intravascular clotting, which may be useful in the diagnosis of VTE. 1-3 In this patient population, the NPV of a negative D-dimer level is high, such that a negative test makes further evaluation for VTE unnecessary.

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Methanol poisoning

Don't Forget the Bubbles

Step 1: Conversion to Formaldehyde Methanol is broken down in the liver by an enzyme called alcohol dehydrogenase at a fixed rate. This zero-order elimination occurs at about ~8–9 mg/dL/hour. How to Calculate the Osmolar Gap The formula for calculated plasma osmolality is: [Na⁺] is the plasma sodium concentration (mEq/L or mmol/L).

Plasma 62
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ToxCard: Iron

EMDocs

1 The incidence of iron overdose and iron ingestion related deaths has significantly decreased over time, likely attributable to federal regulation. 1 Commercially available formulations of iron have varying elemental components. 1 Table 1: Iron content of various preparations. 1 Obtain a single view abdominal x-ray.

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EM@3AM: Systematic Approach to Massive Hemorrhage and Nuances in Special Patient Populations

EMDocs

1 These values can be difficult to quickly assess and measure in a fast-paced clinical scenario. See Figure 1. 9 Current best practice suggests a 1:1:1 administration of PRBC, Platelets, and FFP. Provide 1-2 grams calcium chloride or 3-6 grams calcium gluconate should be administered per MTP round.

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