REBEL EM

SEPTEMBER 13, 2023

Bradykinin Mediated Plasma globulins called kininogens release bradykinin and cause vascular permeability. Image: ( Morgan 2010 ) Features Absence of urticaria and pruritus Insidious onset (24-36 hours) ACE Inhibitors Inhibition of ACE hinders the degradation of bradykinin and can lead to idiosyncratic angioedema.

Frozen Plasma 104

Frozen Plasma Allergic Reaction FFP Plasma 104

Medgadget

OCTOBER 20, 2022

This involves using a plasma ray that glows a pleasing pink color and methane gas as a carbon source. The plasma causes the methane to dissociate into reactive species and then the carbon can be deposited onto the surface of the electrical components. See a video about the technique below. Via: CalTech.

Plasma 92

Plasma ACS 92

Core EM

JULY 23, 2024

Hyperkalemia Cardiac conduction partially depends on a gradient of lower extracellular (plasma) potassium levels and higher intracellular potassium levels. The patient was admitted to the medical intensive care unit and emergent underwent dialysis. His EKG on discharge is shown below.

Plasma 130

Plasma Emergency Department Overdose OR 130

Core EM

JANUARY 24, 2024

Hyperkalemia Cardiac conduction partially depends on a gradient of lower extracellular (plasma) potassium levels and higher intracellular potassium levels. The patient was admitted to the medical intensive care unit and emergent underwent dialysis. His EKG on discharge is shown below.

Plasma 130

Plasma Emergency Department Overdose OR 130

Handtevy

DECEMBER 23, 2024

Association for the Advancement of Blood & Biotherapies (AABB) Resources Standards for Out of Hospital and Prehospital Transfusion Administration Services Coalition Meeting PowerPoints STRAC & PBCFR Protocol Development Stem Cells and Drones TXA and Calcium FDA Regulations FDA Requirement for Blood Palm Beach County Fire Rescue Outcome Data (..)

NFPA 52

NFPA Plasma Emergency Response EMS 52

ALiEM

OCTOBER 20, 2023

Necrobiosis Lipoidica – This patient had a previous skin biopsy with histopathologic changes demonstrating a granulomatous dermatitis involving the dermis and subcutaneous tissues with necrobiosis of collagen and inflammatory infiltrates of lymphocytes and plasma cells consistent with a diagnosis of necrobiosis lipoidica. to 1.2%).

Plasma 161

Plasma Coronary Emergency Department OR 161

Core EM

JANUARY 24, 2024

Background Around 6 million people in the U.S. 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways.

FFP 130

FFP Frozen Plasma Plasma ALS 130

Chicago EMT Training

AUGUST 6, 2021

Various assistant/tech roles around the hospital/Plasma Donation Centers I personally became an Anesthesia Technician at Northwestern solely off of my experience as a paramedic and have been fortunate to bring on coworkers who were EMT students of ours.

EMT 130

EMT EMT Paramedic Plasma 130

The Skeptics' Guide to EM

APRIL 6, 2019

In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozen plasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). Level A One of the concerns clinicians had with DOACs was there was no way to reverse these new anti-coagulants when they were introduced.

Frozen Plasma 130

Frozen Plasma Plasma ALS EMS 130

Pediatric EM Morsels

JUNE 14, 2024

Diagnostic Criterion for ATM (Tavasoli 2018, Wang 2019) Bilateral sensory, motor, and autonomic dysfunction localized to one OR more spinal segment No evidence of compressive cord lesion Enhancing lesion on MRI Pleocytosis or elevated immunoglobulin type G (IgG) index Transverse myelitis consortium working group can be applied to children May (..)

Plasma 144

Plasma ALS OR EMS 144

EMDocs

MAY 23, 2024

3 Measured in analytical testing : Laboratories measure plasma concentration using osmometers which measures values as a function of kilograms of solvent. Choice of the best equation for plasma osmolality calculation: Comparison of fourteen formulae. Validation of equations used to predict plasma osmolality in a healthy adult cohort.

Plasma 89

Plasma EMS ED OR 89

Dr. Smith's ECG Blog

MAY 22, 2024

Don't forget beta agonists in the treatment of hyperkalemia: Terbutaline and Albuterol for Lowering of Plasma Postassium (includes many abstracts) The below abstracts show that beta 2 adrenergic agonists are effective at treating hyperkalemia. Is This a Simple Right Bundle Branch Block? They do so by "shifting" K into the cells. --0.5

Plasma 115

Plasma ICU OR 115

Core EM

OCTOBER 16, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction 188

Allergic Reaction Plasma ED Epinephrine 188

EMDocs

AUGUST 31, 2023

Plasma half-life of the F(ab’) 2 antivenom is significantly longer at 5.5 F(ab) is smaller, consisting of a single antigen binding site, while F(ab’) 2 consists of two antigen-binding sites linked together by an antibody “hinge” region. This size difference may lead to differences in the pharmacokinetic profiles of the two antibodies.

Allergic Reaction 96

Allergic Reaction Plasma ALS EMS 96

EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] 2] This linking group can be either an amide (e.g., lidocaine) or an ester (e.g.,

E-9-1-1 111

E-9-1-1 Plasma Epinephrine Life Support 111

Emergency Medicine Ireland

APRIL 16, 2024

This time the tonicity is high from something else such as high glucose or mannitol drawing water from cells into plasma. A normal sane and functioning kidney will try and lose water to conentrate the plasma in order to bring the sodium back up to normal, in other words the kidney should be producing a dilute urine with a low osm.

Critical Care 74

Critical Care Plasma OR ED 74

Critical Care Scenarios

JANUARY 10, 2021

You may consider remdesevir or convalescent plasma at this point in the science, but don’t expect too much effect.* Very prolonged courses on non-invasive positive pressure ventilation (CPAP/BiPAP) may be more acceptable here than in other diseases; although not very appealing it may be preferable to intubation.

Critical Care 100

Critical Care Plasma ICU OR 100

Critical Care Scenarios

OCTOBER 31, 2021

Plasma free hemoglobin levels may be a useful marker that changing your oxygenator could improve gas exchange.* .* Hypoxemia can occur in VV ECMO patients due to too much flow through the native circulation and shunted lungs. In such cases, beta blockade may actually improve systemic oxygenation.*

Interfacility Transport 100

Interfacility Transport Plasma ICU EMS 100

Emergency Medicine Ireland

MARCH 13, 2023

In broad terms we can compare dialysis (the movement of small molecules across a membrane along an osmotic gradient) with ultrafiltration (the squeezing of plasma through a big sieve that retains the big bits of the plasma and lets the other bits leak out).

Critical Care 52

Critical Care Plasma ICU OR 52

Medgadget

MAY 11, 2023

Red cells are healthy monocytes, green and yellow are plasma cells. Study in Nature Cancer : Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma Image credit: Bone-​marrow cells of a multiple myeloma patient. Image: Berend Snijder Lab / ETH Zurich) Via: ETH Zurich

Plasma 79

Plasma OR 79

Emergency Medicine Ireland

JUNE 7, 2021

In the plasma itself, 50% is ionised, 40% is plasma bound and 10% is chelated to various anions. There is a large gradient between the ionised calcium in the plasma and the tiny ionised fraction in the cells. So as an important starter, the serum level of calcium does not tell us much about overall levels in the body.

Critical Care 52

Critical Care Plasma ICU OR 52

Emergency Medicine Ireland

MARCH 7, 2022

On the other hand, lymphoid cells have a much smaller and narrower family tree differentiating into different types of lymphocytes and plasma cells. This is a cancer of plasma cells which are the grown up and left home versions of B lymphocytes. Finally on the list of common haematological malignancies is multiple myeloma.

Critical Care 52

Critical Care Plasma ICU OR 52

Emergency Medicine Ireland

FEBRUARY 11, 2021

Up front there are some problems with the terminology * Plasmapheresis = process of removing plasma from the blood.

Critical Care 40

Critical Care Plasma ICU OR 40

The Overrun Podcast

MAY 23, 2019

Mark Merlin on Twitter at : @ccareanywhere The NJ EMS and Disaster Medicine Fellowship can be found at: www.emsfellowship.com The MD1 physician response program: www.md1program.org Dr. Qasim is on Twitter at: @emeddoc Dr. Callelo: @DrDianeC, @njpoisoncenter, also at @ToxAndHound The COMBAT trial for prehospital plasma: [link] The PAMPHER trial: [link] (..)

EMS 52

EMS Plasma Epinephrine CPR 52

The Overrun

JUNE 3, 2023

Through the years, we see a change to plasma, then crystalloid, and then 1:1:1 therapy. Once compared, while 1:1:1 therapy or giving PRBCs or plasma alone is better than crystalloid, whole blood is preferable and may have more of a survival benefit for patients. In the First World War, the preferred resuscitation fluid was whole blood.

Plasma 52

Plasma Paramedicine Paramedicine EMS 52

The Overrun Podcast

NOVEMBER 23, 2020

We also talk about education, and how The Church is looking to educate while still having a laugh or two. Dr. Fisher’s Twitter feed: [link] Kotwal, et al.

EMT 52

EMT EMT Plasma Paramedic 52

K.S. Chew

APRIL 29, 2015

According to the AHA 2005 on CPR & ERC, it says:"Absorption and subsequent achievement of maximum plasma concentration after subcutaneous administration is slower and may be significantly delayed with shock. IM vs SC - which is preferred? Thus, intramuscular (IM) administration is favored."Thus,

Plasma 40

Plasma CPR 40

Emergency Medicine Ireland

MARCH 11, 2021

Plasmapheresis (which involves spinning the blood in a big machine until the plasma separates out, then removing all the plasma and replacing the volume with some 5% albumin and letting the body reproduce all the other plasma components itself) is another treatment supported by a 2012 Cochrane review of randomised trials.

Critical Care 40

Critical Care Plasma ICU OR 40

The EMS Show

NOVEMBER 17, 2023

PACT Trial: [link] Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemmorhagic Shock: [link] Guyette is a Professor of Emergency Medicine, University of Pittsburgh Medical Director - STAT MedEVAC as well as the Principal Investigator for the ongoing PACT Trial.

Medical Transportation 40

Medical Transportation Plasma EMS 40

The EMS Show

NOVEMBER 17, 2023

PACT Trial: [link] Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemmorhagic Shock: [link] Guyette is a Professor of Emergency Medicine, University of Pittsburgh Medical Director - STAT MedEVAC as well as the Principal Investigator for the ongoing PACT Trial.

Medical Transportation 40

Medical Transportation Plasma EMS 40

Emergency Medicine Ireland

APRIL 29, 2024

If it’s rising too quick it’s often because the patient is losing lots of water through the kidneys which concentrates the plasma raising the Na in the blood. If it’s rising too quick it’s often because the patient is losing lots of water through the kidneys which concentrates the plasma raising the Na in the blood.

Critical Care 75

Critical Care Plasma OR ED 75

International Journal of Paramedicine

JANUARY 5, 2024

Results - A higher shock index score after arrival to the emergency department experienced longer hospital, intensive care unit, and mechanical ventilation days, injury severity scores, packed red blood cells, plasma, platelets, and total blood product usage. Mortality was higher in the groups with an SI of ≥ 0.9

Emergency Department 52

Emergency Department Plasma OR 52

EMDocs

NOVEMBER 20, 2023

For patients on VKAs to prevent stroke in nonvalvular atrial fibrillation who require reversal, 4-factor prothrombin complex concentrate (PCC) is preferred to fresh frozen plasma (FFP) because of the rapidity of INR reduction (Conditional recommendation, very low-quality evidence).

Frozen Plasma 103

Frozen Plasma FFP Plasma OR 103

Medgadget

JULY 19, 2023

Study in journal ACS Nano : STAMP-Based Digital CRISPR-Cas13a for Amplification-Free Quantification of HIV-1 Plasma Viral Loads Via: Penn State By counting the signals, researchers can quantify the viral load in a sample. Credit: Provided by Weihua Guan.

Plasma 56

Plasma ACS 56

Core EM

OCTOBER 2, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction 100

Allergic Reaction Plasma ED Epinephrine 100

Don't Forget the Bubbles

AUGUST 2, 2023

Pro-inflammatory states may also play a role, as patients with CRPS have significantly higher levels of plasma cytokines and chemokines. Several neurological mechanisms for CRPS have been suggested, including central sensitisation, alteration in the central nervous system (CNS), and small fibre changes.

MPD 98

MPD ALS Plasma OR 98

EMDocs

JULY 13, 2024

Plasma cell endometritis is associated with Chlamydia trachomatis infection. Chorioamnionitis and endometritis. Infect Dis Clin North Am. 1997 Mar;11(1):203-22. doi: 10.1016/s0891-5520(05)70349-4. PMID: 9067792. Paukku M, Puolakkainen M, Paavonen T, Paavonen J. Am J Clin Pathol. 1999 Aug;112(2):211-5. doi: 10.1093/ajcp/112.2.211.

EMS 87

EMS E-9-1-1 Plasma OR 87